Jeffery was born in Houston, Texas and has been performing since the age of 17. He grew up in Cincinnati, Ohio, performing in numerous community venues. He and his family moved to Los Angeles in 2005 so he could pursue a career his music and acting.
Within the next year, he landed his first notable acting role, a guest appearance in It's Always Sunny in Philadelphia. He also guest starred on the Oprah Show in 2007, he had a three-episode stint in the drama Heroes. His other television credits include Bones and Trust Me, and The Color Purple.</p>
He currently co-stars as Cameron Parks in the Disney Channel sitcom A.N.T. Farm, which premiered in 2011. His character for two seasons has been a series regular, but will be demoted down to recurring character in the third season and Aedin Mincks will take his place.
In music, Jeffery is also a rapper, performing under the pseudonym Lil' C-Note. He has a twin sister, Carla Jeffery, who is also an actress.